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![8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/acs.jmedchem.5b01635/asset/images/acs.jmedchem.5b01635.social.jpeg_v03 "8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors | Journal of Medicinal Chemistry")